Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models
نویسندگان
چکیده
منابع مشابه
Correlation between tumor engraftment in patient-derived xenograft models and clinical outcomes in colorectal cancer patients
Despite numerous studies involving patient-derived xenograft (PDX) models, few studies have investigated the relationship between the ability of the tumor to engraft (tumorigenicity) and the clinical features of colorectal cancer (CRC). The aim of this study was to determine whether tumorigenicity correlates with clinical outcomes of CRC patients. We included 241 CRC patients who underwent radi...
متن کاملTargeting MEK and CDK4/6 in KRAS Mutant Colorectal Cancers Abbreviations: CRC: colorectal cancer; PDX: patient-derived xenograft
Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy that Co-Targets MEK and CDK4/6 Elizabeth K. Ziemke, Joseph S. Dosch, Joel D. Maust, Amrith Shettigar , Ananda Sen, Theodore H. Welling, Karin M. Hardiman, Judith S. Sebolt-Leopold Translational Oncology Program, Department of Radiology, Department of Pharmacology, Department of Family Medicine, Department of Surgery, Universit...
متن کاملPatient-Derived Xenograft (PDX) Models: An Emerging Platform for Cancer Drug Development and Translational Research
Previously, cancer drug development was an arena that relied almost exclusively on transgenic and severely compromised immuno-deficient (SCID) mice to measure tumor growth in response to novel therapeutic drugs. Development has now evolved to the point where several different murine models are now employed. The industry has expanded to include syngeneic and humanized mice, in addition to PDX mo...
متن کاملPatient-derived xenograft (PDX) tumors increase growth rate with time
Patient-derived xenograft (PDX) models are frequently used for translational cancer research, and are assumed to behave consistently as the tumor ages. However, growth rate constancy as a function of time is unclear. Notably, variable PDX growth rates over time might have implications for the interpretation of translational studies. We characterized four PDX models through several in vivo passa...
متن کاملDevelopment of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model
Bone metastasis is a complex process that needs to be better understood in order to help clinicians prevent and treat it. Xenografts using patient-derived material (PDX) rather than cancer cell lines are a novel approach that guarantees more clinically realistic results. A primary culture of bone metastasis derived from a 67-year-old patient with breast cancer was cultured and then injected int...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2018
ISSN: 0020-7136
DOI: 10.1002/ijc.31767